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Forty-two percent of AIDS cases in Philadelphia are related to sharing syringes and other equipment for injecting drugs. Traditional means of HIV prevention such as education and condom distribution are limited in their capacity to reduce the spread of HIV among injection drug users and their sexual partners because many are not ready to stop using drugs. To address this issue, Prevention Point Philadelphia (PPP) has created a broad spectrum of public health services for injection drug users to mitigate their risk for HIV and other drug-related harm.